Coumou J, Wagemakers A, Narasimhan S, Schuijt TJ, Ersoz JI, Oei A, de Boer OJ, Roelofs JJTH, Fikrig E, Hovius JW (2019). The role of Mannose Binding Lectin in the immune response against Borrelia burgdorferi sensu lato. Scientific reports9(1), 1431. doi:10.1038/s41598-018-37922-8 Open access

Pospisilova, T., V. Urbanova, O. Hes, P. Kopacek, O. Hajdusek and R. Sima (2019). Tracking of Borrelia afzelii transmission from infected Ixodes ricinus nymphs to mice. Infection and Immunity: IAI.00896-00818. Open access

Mihajlović J, Hovius JWR, Sprong H, Bogovič P, Postma MJ, Strle F. (2019) Cost-effectiveness of a potential anti-tick vaccine with combined protection against Lyme borreliosis and tick-borne encephalitis in Slovenia. Ticks Tick Borne Dis. 2019 Jan;10(1):63-71. Open access

Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission Ryan Rego; Jos Trentelman; Juan Anguita; Ard M. Nijhof; Hein Sprong; Boris Klempa; Ondrej Hajdusek; Julen Tomás-Cortázar; Tal Azagi; Martin Strnad; Sarah Knorr; Radek Sima; Marie Jalovecka; Sabína Fumačová Havlíková; Martina Ličková; Monika Sláviková; Petr Kopacek; Libor Grubhoffer; Joppe W. Hovius. Submitted forOpen access publication. 


Formaglio, P., J. W. Hovius, C. Aditya, J. Tavares, L. M. K. Mason, R. Ménard, N. Boulanger and R. Amino (2018). Chapter 12 - Tools to Decipher Vector-Borne Pathogen and Host Interactions in the Skin. Skin and Arthropod Vectors. N. Boulanger, Academic Press: 431-467 (Indirectly related to the ANTIDotE project)

Špitalská E, Sparagano O, Stanko M, Schwarzová K, Špitalský Z, Škultéty Ľ, Havlíková SF. Diversity of Coxiella-like and Francisella-like endosymbionts, and Rickettsia spp., Coxiella burnetii as pathogens in the tick populations of Slovakia, Central Europe. Ticks Tick Borne Dis. 2018;9:1207-1211. (Indirectly related to the ANTIDotE project)

Vechtova P, Sterbova J, Sterba J, Vancova M, Rego ROM, Selinger M, Strnad M, Golovchenko M, Rudenko N, Grubhoffer L. A bite so sweet: the glycobiology interface of tick-host-pathogen interactions. Parasit Vectors. 2018 Nov 14;11(1):594 Open access

Mason LMK, Coumou J, Ersöz JI, Oei A, Roelofs JJTH, Vogl T, van der Poll T, Hovius JWR. MRP8/14 does not contribute to dissemination or inflammation in a murine model of Lyme borreliosis. Immunobiology. 2018 Nov;223(11):694-698. Open access  (Indirectly related to the ANTIDotE project)

Sarah Knorr; Juan Anguita; Julen T Cortazar; Ondrej Hajdusek; Petr Kopacek; Jos J Trentelman; Olivia Kershaw; Joppe W Hovius; Ard Menzo Nijhof. Preliminary evaluation of tick protein extracts and recombinant Ferritin 2 as anti-tick vaccines targeting Ixodes ricinus in cattle. Front Physiol 2018, 9: 1696.

Sprong H, Azagi T, Hoornstra D, Nijhof AM, Knorr S, Baarsma ME, Hovius JW. Control of Lyme borreliosis and other Ixodes ricinus-borne diseases. Parasit Vectors. 2018 Mar 6;11(1):145.doi: 10.1186/s13071-018-2744-5.Open access 

Hovius KE, de Bruin A, Schouls L, Hovius JW, Dekker N, Sprong H. A lifelong study of a pack Rhodesian ridgeback dogs reveals subclinical and clinical tick-borne Anaplasma phagocytophilum infections with possible reinfection or persistence. Parasit Vectors. 2018 Apr 12;11(1):238. Open access (Indirectly related to the ANTIDotE project)

Urbanova, V., Hajdusek, O., Sima, R., Franta, Z., Honig-Mondekova, H., Grunclova, L., Bartosova-Sojkova, P., Jalovecka, M., Kopacek, P., 2018. IrC2/Bf - A yeast and Borrelia responsive component of the complement system from the hard tick Ixodes ricinus. Dev Comp Immunol 79, 86-94. doi: 10.1016/j.dci.2017.10.012. (Indirectly related to the ANTIDotE project)


Abstract: Mihajlović J, Hovius J, Sprong H, Strle F, Bogovič P, Postma M (2017) Cost-Abstract: Mihajlović J, Hovius J, Sprong H, Strle F, Bogovič P, Postma M (2017) Cost-Effectiveness Of A Potential Combined Vaccine Against Lyme Borreliosis And Tick-BorneEncephalitis In Slovenia. Value in Health Open access 

J. Tomás-Cortázar, I. Martín-Ruiz, D. Barriales, M.A. Pascual-Itoiz, V. Gutiérrez de Juan, A.Caro-Maldonado, N. Merino, A. Marina, F.J. Blanco, J.M. Flores, J.D. Sutherland, R. Barrio, A. Rojas,M.L. Martínez-Chantar, A. Carracedo, C. Simó, V. García-Cañas, L. Abecia, J.L. Lavín, A.M. Aransay,H. Rodríguez, J. Anguita. 2017. The immunosuppressive effect of the tick protein, Salp15, is longlasting and persists in a murine model of hematopoyetic transplant. Scientific Reports. 7:10740. Open access 

Strnad M, Hönig V, Růžek D, Grubhoffer L, Rego R.O.M. 2017. Europe-Wide Meta-Analysisof Borrelia burgdorferi Sensu Lato Prevalence in Questing Ixodes ricinus Ticks. Applied andEnvironmental Microbiology 83(15) Open access

Urbanova, V., Hajdusek, O., Honig Mondekova, H., Sima, R., Kopacek, P., 2017. Tick Thioester-Containing Proteins and Phagocytosis Do Not Affect Transmission of Borrelia afzelii from the Competent Vector Ixodes ricinus. Front Cell Infect Microbiol 7, 73. doi:10.3389/fcimb.2017.00073. Open access

Honig Mondekova, H., Sima, R., Urbanova, V., Kovar, V., Rego, R.O.M., Grubhoffer, L., Kopacek, P., Hajdusek, O., 2017. Characterization of Ixodes ricinus Fibrinogen-Related Proteins(Ixoderins) Discloses Their Function in the Tick Innate Immunity. Front Cell Infect Microbiol 7,509. doi: 10.3389/fcimb.2017.00509. Open access

Narasimhan S, Schuijt TJ, Abraham NM, Rajeevan N, Coumou J, Graham M, Robson A, Wu MJ, Daffre S, Hovius JW, Fikrig E. Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization. Nat Commun. 2017 Aug 4;8(1):184. Open access


A. Smith, N. Navasa, X. Yang, C.N. Wilder, O. Buyuktanir, A. Marques, J. Anguita, U. Pal. 2016. Cross-species interferon signaling boosts microbicidal activity within the tick vector. Cell Host & Microbe. 20:91-98. Open access. (Including a commentary by A.M. de Silva. 2016. Ticks Take Cues from Mammalian Interferon. Cell Host & Microbe. 20:3-4).

Abstract : Mihajlović J, Hovius J, Sprong H, Strle F, Bogovič P, Postma M (2016) Mathematical Model to Synthesize Natural History of Tick Borne Encephalitis and LymeBorreliosis for the Purpose of Cost-Effectiveness Analysis. Value in Health Open access

Steere AC, Strle F, Wormser GP, Hu LT, Branda JA, Hovius JW, Li X, Mead PS. Lyme borreliosis. Nat Rev Dis Primers. 2016 Dec 15;2:16090. doi: 10.1038/nrdp.2016.90. Review. As part of this overview article on Lyme borreliosis, old, existing and future preventive strategies to prevent Lyme borreliosis and other tick-borne diseases are discussed (including anti-tick vaccines). 

Wagemakers A, Coumou J, Schuijt TJ, Oei A, Nijhof AM, van 't Veer C, van der Poll T, Bins AD, Hovius JW. An Ixodes ricinus Tick Salivary Lectin Pathway Inhibitor Protects Borreliaburgdorferi sensu lato from Human Complement. Vector Borne Zoonotic Dis. 2016 Apr;16(4):223-8.

Coumou J, Narasimhan S, Trentelman JJ, Wagemakers A, Koetsveld J, Ersoz JI, Oei A, Fikrig E, Hovius JW. Ixodes scapularis dystroglycan-like protein promotes Borrelia burgdorferi migration from the gut. J Mol Med (Berl). 2016 Mar;94(3):361-70. Open access 

Michelle J. Klouwens, Jos J. Trentelman Joppe W Hovius. Anti-tick vaccines to prevent tick-borne diseases; an overview and a glance at the future. Bookchapter in Ecology and Control of Vector-borne diseases: 4 () - Pages: 295 – 316. Published Online: November 28, 2016. We describe the state of the art concerning anti-tick vaccines and the future including the ANTIDotE project. Open access

Sprong H, Braks MAH (2016) Choosing One-Health Approach for the control of Lyme borreliosis. In: Ecology and Prevention of Lyme borreliosis p11-18. Wageningen: Wageningen Academic Publishers Open access

Kaaijk P, Sprong H, van de Wijngaard C, Luytjes W (2016) Vaccineren tegen Lyme: Hoe ver staan we? Infectieziekten Bulletin 27:197-201

Khasnatinov MA, Tuplin A, Gritsun DJ, Slovak M, Kazimirova M, Lickova M, Havlikova S, Klempa B, Labuda M, Gould EA, Gritsun TS. Tick-Borne Encephalitis Virus Structural Proteins Are the Primary Viral Determinants of Non-Viraemic Transmission between Ticks whereas Non-Structural Proteins Affect Cytotoxicity. PLoS One. 2016;11:e0158105. Open access  (Indirectly related to the ANTIDotE project)


Coumou J, Wagemakers A, Trentelman JJ, Nijhof AM, Hovius JW. Vaccination against Bm86 Homologues in Rabbits Does Not Impair Ixodes ricinus Feeding or Oviposition. PLoS One. 2015 Apr 28;10(4):e0123495. Open access

Strnad, M. et al. Correlative cryo-fluorescence and cryo-scanning electron microscopy as a straightforward tool to study host-pathogen interactions. Sci. Rep. 5, 18029; doi: 10.1038/srep18029 (2015).

Ayllón N, Naranjo V, Hajdušek O, Villar M, Galindo RC, Kocan KM, Alberdi P, Šíma R, Cabezas-Cruz A, Rückert C, Bell-Sakyi L, Kazimírová M, Havlíková S, Klempa B, Kopáček P, de la Fuente J. Nuclease Tudor-SN Is Involved in Tick dsRNA-Mediated RNA Interference and Feeding, but Not in Defense against Flaviviral or Anaplasma phagocytophilum Infection. PLoS One. 2015;10:e0133038. Open access


Sprong H, Trentelman J, Seemann I, Grubhoffer L, Rego R, Hajdušek O, Kopáček P, Šíma R, Nijhof A, Anguita J, Winter P, Rotter B, Havlíková S, Klempa B, Schetters T, Hovius J (2014) ANTIDotE: Anti-tick Vaccines to Prevent Tick-borne Diseases in Europe. Parasites & Vectors 7:77. Open access

Frey S, Essbauer S, Zöller G, Klempa B, Dobler G, Pfeffer M. Full genome sequences and preliminary molecular characterization of three tick-borne encephalitis virus strains isolated from ticks and a bank vole in Slovak Republic. Virus Genes. 2014;48:184-8.  (Indirectly related to the ANTIDotE project)

Slovák M, Kazimírová M, Siebenstichová M, Ustaníková K, Klempa B, Gritsun T, Gould EA, Nuttall PA. Survival dynamics of tick-borne encephalitis virus in Ixodes ricinus ticks. Ticks Tick Borne Dis. 2014;5:962-9.

Ruiz-Fons F, Balseiro A, Willoughby K, Oleaga A, Dagleish MP, Perez-Ramirez E, Havlikova S, Klempa B, Llorente F, Paz Martin-Hernando M. Clinical infection of Cantabrian chamois (Rupicapra pyrenaica parva) by louping ill virus: new concern for mountain ungulate conservation? Eur J Wildl. Res 2014;60:691.  (Indirectly related to the ANTIDotE project)

Narasimhan S, Coumou J, Schuijt TJ, Boder E, Hovius JW, et al. (2014) A Tick Gut Protein with Fibronectin III Domains Aids Borrelia burgdorferi Congregation to the Gut during Transmission. PLOS Pathogens 10(8): e1004278 Open access